In Vitro and In Vivo Evaluation of Hydroxyzine Hydrochloride Microcapsules for skin delivery
نویسندگان
چکیده
629 ©2011 Society For Biomaterials Conflict of Interest: No conflict of interest or any financial benefit is required from all co-authors. Any experiments involving the use of animals were conducted in accordance with the principles of Laboratory Animal care and were approved by the Ethical Committee of the Faculty of Pharmacy ,Cairo University, Egypt.
منابع مشابه
In vitro and in vivo evaluation of a novel testosterone transdermal delivery system (TTDS) using palm oil base
Objective (s): Transdermal preparations for testosterone are becoming popular because of their unique advantages such as avoidance of first-pass effect, convenience, improved bioavailability, and reduction of systemic side effects. A novel testosterone transdermal delivery system (TDDS) was developed using a palm oil base called HAMINTM (a commercial product) and tested using in vitro and in vi...
متن کاملIn vitro transdermal delivery of propranolol hydrochloride through rat skin from various niosomal formulations
Objective(s): The purpose of the present study was to prepare and to evaluate a novel niosome as transdermal drug delivery system for propranolol hydrochloride and to compare the in vitro efficiency of niosome by either thin film hydration or hand shaking method. Materials and Methods: Niosomes were prepared by Thin Film Hydration (TFH) or Hand Shaking (HS) method. Propranolol niosomes were pre...
متن کاملSynergistic Effect of Chemical Enhancer And Iontophoresis For Transdermal Delivery Of Nebivolol Hydrochloride
The aim of the present study was to develop and investigate the feasibility of delivering Nebivolol as a transdermal patch by iontophoresis. The passive and electrically assisted transdermal delivery of Nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. Because of its extensive hepatic metabolism and low dos...
متن کاملPreparation and Evaluation of Modified Proniosomal Gel for Localised Urticaria and Optimisation by Statistical Method
The objective of the study was to formulate a modified proniosomal gel (HMPG) of hydroxyzine hydrochloride. HMPG formulations were prepared by coacervation phase separation technique with different combination of non-ionic surfactants (Tweens and Spans) with phospholipids such as phospholipon 80H and 90H. Taguchi design of experiments was used to optimize the various formulation variables. The ...
متن کاملFeasibility of Calcium Alginate Microcapsules of Oral Sustained Release Suspensions of Propranolol Hydrochloride Using Ion Exchange Resinates
An oral suspension could a suitable dosage form for the geriatric patients. The calcium alginate coated ion exchange resinate of propranolol hydrochloride were prepared using Amberlite IR-120 by solvent evaporation. Microcapsules of propranolol hydrochloride resinate were prepared by solvent evaporation technique,the suspensions were prepared by using deionised water as the vehicle. Methy...
متن کامل